Endocrine Abstracts

Background: 55 year-old male is admitted in 2019 to the hospital for relapsed MEN syndrome.Case report: The pacient first presented to the hospital in march 2012 acusing dysphonia. He was diagnosed with vocal cord paralysis due to locoregional extension of MTC, based on the ultrasound aspect, calcitonin >2000 pg/mL, chromogranin=123 ng/mL and also with primary hyperparathyroidism due to right lower parathyroid adenoma (hypercalcemia=12.8 mg/dl, PTH=2...

Introduction: MEN1 is a rare syndrome characterised by hyperplasia or neoplasm of the parathyroid glands, pituitary, pancreas or duodenum and can associate, less frequently, phaeochromocytoma, thymic or bronchial carcinoids, multiple lipomas, cutaneous angiofibromas and thyroid adenomas.Case report: A 47-year-old woman with MEN1 presenting parathyroid recurrent adenomas, a pituitary prolactin-growth hormone cosecreting macroadenoma, associated with an in...

Given the increasing incidence in psychiatric pathology, adverse reactions of psychotropic medications, especially the metabolic and endocrine side effects, are encountered more frequently in clinical practice. We present the cases of two female patients with psychiatric pathology, in whom the specific treatment was accompanied by significant endocrine adverse reactions, making the tumoural differential diagnosis very difficult. The first case is of a patient aged 61 years, kn...

Objectives: Endothelial dysfunction has been described as a predictor of cardiovascular complications. Most important cause for early mortality in acromegaly is cardiovascular involvement, cut-off nadir GH <2.5 ng/ml predicting longer survival The aim of our study was to determine the correlations between endothelial dysfunction and GH oversecretion, associated or not with other cardiovascular risk factors.Design and method: Cross-sectional study inc...

Objectives: Metabolic syndrome, especially obesity and diabetes are associated and responsible for a depressive psychological status. Meanwhile, antidepressors are responsible for metabolic disturbances, such as insulin resistance. The study aims to determine predictive factors of response to antidepressant pharmacotherapy in patients with metabolic syndrome.Materials and methods: A retrospective study conducted in Institute Parhon’s Department for ...

Objective: CT findings indicating that a patient is at risk for developing optic neuropathy are worth- while observations.Aim: The aim of our study was to determine the utility of CT imaging in identifying patients at risk for optic neuropathy and to compare quantifiable nonvolumetric CT data from a large series of orbits with Graves ophthalmopathy.Method: A total of 226 patients (452 orbits), 175 women (350 orbits) and 51 men (102...

Introduction: Although thyrotoxicosis is considered to be a very rare finding in a patient with thyroid cancer, there are several reports regarding this unexpected association in specialty literature. A frequent cause of thyrotoxicosis in patients with cardiac disease is amiodarone-induced thyroid dysfunction. The mechanism underlying this adverse reaction can be attributed to high iodine content and the direct toxic effect of the drug on thyroid cells.C...

Adult-onset hypopituitarism is a frequently delayed diagnosis because of the insidious debut and non-specific symptoms, frequently attributed to normal aging or many other pathologies - fatigue, malaise, cognitive impairment, decreased libido. Left untreated, it can have severe consequences with vital impact.Case-report: We present the case of a female patient, aged 69, who was initially addressed for evaluation of hypercalcemia. She had had four live bi...

46, XY complete gonadal dysgenesis, also known as Swyer Syndrome, is characterized by the presence of normal female external genitalia at birth, late puberty and primary amenorrhea. Spontaneous menses (due to hormone-secreting tumor) and breasts development occur in rare cases. With proper hormonal substitution, patients could carry pregnancies achieved through IVF with donor oocytes.Case presentationFemale patient, aged 22, addres...

Introduction: Parathyroid carcinoma represents a very rare cause of primary hyperparathyroidism. It can be sporadic (most of cases), but also can occur in association with certain syndromes (multiple endocrine neoplasia, hyperparathyroidism-jaw tumor syndrome or isolated familial hyperparathyroidism).Case report: An 18-year-old woman was referred to the endocrine clinic because of a severe hypercalcemia, detected in the orthopedic surgery department, whe...